Comorbidity of mental disorders is a major problem for mental health research and practice. The lab aims to address this problem by employing a transdiagnostic, dimensional, and neuroscience-informed approach to the study of the etiology and development of multiple forms of psychopathology. Instead of relying on traditional diagnostic categories, we aim to study the shared variation and dimensionality among mental disorder symptoms (i.e., comorbidity and severity) to identify common features of psychopathology across internalizing, externalizing, and thought disorder spectra. To do this, we combine clinical (e.g., diagnostic interview and questionnaire), behavioral (e.g., neurocognitive, affective, personality testing), and multi-modal neuroimaging (e.g., structural and functional MRI) methods to examine shared risk markers of psychopathology at multiple levels of analysis in adolescents and adults. The ultimate goal of this research is to provide novel insights on transdiagnostic targets for interventions to improve outcomes for individuals whose symptoms span traditional diagnostic categories.